Variation in Neonatal Transfusion Practice
| Autor: | Patel, Ravi M, Hendrickson, Jeanne E, Nellis, Marianne E, Birch, Rebecca, Goel, Ruchika, Karam, Oliver, Karafin, Matthew S, Hanson, Sheila J, Sachais, Bruce S, Hauser, Ronald George, Luban, Naomi LC, Gottschall, Jerome, Josephson, Cassandra D, Sola-Visner, Martha, National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P) |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Datasets as Topic and Blood Institute Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric Gestational Age Practice Patterns red blood cell Reproductive health and childbirth Low Birth Weight and Health of the Newborn Pediatrics Cohort Studies Paediatrics and Reproductive Medicine Hemoglobins blood Preterm Infant Mortality Humans Blood Transfusion International Normalized Ratio Aetiology Lung plasma platelet Pediatric Physicians' Platelet Count Incidence Infant National Heart Hematology Human Movement and Sports Sciences Perinatal Period - Conditions Originating in Perinatal Period Newborn infant United States Female preterm 2.4 Surveillance and distribution |
| Popis: | ObjectiveTo estimate the incidence of blood product transfusion, including red blood cells, platelets, and plasma, and characterize pretransfusion hematologic values for infants during their initial hospitalization after birth.Study designRetrospective cohort study using data from 7 geographically diverse US academic and community hospitals that participated in the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) from 2013 to 2016. Pretransfusion hematologic values were evaluated closest to each transfusion and no more than 24hours beforehand.ResultsData from 60 243 infants were evaluated. The incidence of any transfusion differed by gestational age (P45 for all gestational age groups examined. The median pretransfusion international normalized ratio for the entire cohort was 1.7 (10th-90th percentile 1.2-2.8).ConclusionsThere is wide variability in pretransfusion hemoglobin, platelet count, and international normalized ratio values for neonatal transfusions. Our findings suggest that a large proportion of neonatal transfusions in the US are administered at thresholds greater than supported by the best-available evidence and highlight an opportunity for improved patient blood management. |
| Databáze: | OpenAIRE |
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