Stability of the gut microbiota in persons with paediatric-onset multiple sclerosis and related demyelinating diseases
| Autor: | Liang, Geoffrey, Zhu, Feng, Mirza, Ali I, Bar-Or, Amit, Bernstein, Charles N, Bonner, Christine, Forbes, Jessica D, Graham, Morag, Hart, Janace, Knox, Natalie C, Marrie, Ruth Ann, O'Mahony, Julia, Van Domselaar, Gary, Yeh, E Ann, Zhao, Yinshan, Banwell, Brenda, Waubant, Emmanuelle, Tremlett, Helen, Canadian Paediatric Demyelinating Disease Network |
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| Rok vydání: | 2022 |
| Předmět: |
Multiple Sclerosis
paediatric Neurology & Neurosurgery gut microbiota Clinical Sciences Neurosciences Syndrome stability Neurodegenerative monophasic acquired demyelinating syndrome Autoimmune Disease Gastrointestinal Microbiome demyelinating disease Brain Disorders Humans Child Canadian Paediatric Demyelinating Disease Network |
| Zdroj: | Multiple sclerosis (Houndmills, Basingstoke, England), vol 28, iss 11 |
| Popis: | ObjectiveExamine if the gut microbiota composition changes across repeated samples in paediatric-onset multiple sclerosis (MS) or monophasic-acquired demyelinating syndromes (monoADS).MethodsA total of 36 individuals (18 MS/18 monoADS) with ⩾2 stool samples were included. Stool sample-derived DNA was sequenced. Alpha/beta diversities and genus-level taxa were analysed.ResultsMean ages at first sample procurement (MS/monoADS) = 18.0/13.8 years. Median time (months) between first/second samples = 11.2 and second/third = 10.3. Alpha/beta diversities did not differ between stool samples (p > 0.09), while one genus - Solobacterium did (p = 0.001).ConclusionsThe gut microbiota composition in paediatric-onset MS and monoADS exhibited stability, suggesting that single stool sample procurement is a reasonable first approach. |
| Databáze: | OpenAIRE |
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