The association between subclinical thyroid dysfunction and dementia: The Health, Aging and Body Composition (Health ABC) Study
| Autor: | Aubert, Carole E, Bauer, Douglas C, da Costa, Bruno R, Feller, Martin, Rieben, Carole, Simonsick, Eleanor M, Yaffe, Kristine, Rodondi, Nicolas, Health ABC Study |
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| Rok vydání: | 2017 |
| Předmět: |
cognitive ageing
Aging thyroid dysfunction Prevention Clinical Sciences Thyroid Gland Thyrotropin Neurodegenerative cognitive decline Hyperthyroidism Brain Disorders Paediatrics and Reproductive Medicine Endocrinology & Metabolism Hypothyroidism Clinical Research Health ABC Study Neurological Acquired Cognitive Impairment Humans Dementia Prospective Studies Aged |
| Zdroj: | Clinical endocrinology, vol 87, iss 5 |
| Popis: | ObjectiveData on the association between subclinical thyroid dysfunction and dementia are limited and conflicting. We aimed to determine whether subclinical thyroid dysfunction was associated with dementia and cognitive decline.DesignPopulation-based prospective cohort study.PatientsAdults aged 70-79years with measured thyroid function, but no dementia at baseline, and Modified Mini-Mental State (3MS) at baseline and follow-up.MeasurementsPrimary outcome was incident-adjudicated dementia, based on 3MS, hospital records and dementia drugs. Secondary outcome was change in 3MS. Models were adjusted for age, sex, race, education and baseline 3MS, and then further for cardiovascular risk factors.ResultsAmong 2558 adults, 85% were euthyroid (TSH 0.45-4.49mIU/L), 2% had subclinical hyperthyroidism with mildly decreased TSH (TSH 0.10-0.44mIU/L), 1% subclinical hyperthyroidism with suppressed TSH (TSH |
| Databáze: | OpenAIRE |
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