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AimsThe intermediate-term effects of dietary protein on cardiometabolic risk factors in overweight and obese patients with heart failure and diabetes mellitus are unknown. We compared the effect of two calorie-restricted diets on cardiometabolic risk factors in this population.Methods and resultsIn this randomized controlled study, 76 overweight and obese (mean weight, 107.8±20.8kg) patients aged 57.7±9.7years, 72.4% male, were randomized to a high-protein (30% protein, 40% carbohydrates, and 30% fat) or standard-protein diet (15% protein, 55% carbohydrates, and 30% fat) for 3months. Reductions in weight and cardiometabolic risks were evaluated at 3months. Both diets were equally effective in reducing weight (3.6 vs. 2.9kg) and waist circumference (1.9 vs. 1.3cm), but the high-protein diet decreased to a greater extent glycosylated haemoglobin levels (0.7% vs. 0.1%, P=0.002), cholesterol (16.8 vs. 0.9mg/dL, P=0.031), and triglyceride (25.7 vs. 5.7mg/dL, P=0.032), when compared with the standard-protein diet. The high-protein diet also significantly improved both systolic and diastolic blood pressure than the standard-protein diet (P |
