| Autor: |
Shrestha, U, Sciammarella, M, Alhassen, F, Yeghiazarians, Y, Ellin, J, Verdin, E, Boyle, A, Seo, Y, Botvinick, EH, Gullberg, GT |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Zdroj: |
Shrestha, U; Sciammarella, M; Alhassen, F; Yeghiazarians, Y; Ellin, J; Verdin, E; et al.(2017). Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and99mTc-tetrofosmin: Method and validation. Journal of Nuclear Cardiology, 24(1), 268-277. doi: 10.1007/s12350-015-0320-3. UCSF: Retrieved from: http://www.escholarship.org/uc/item/8vf612q2 |
| Popis: |
© 2015, American Society of Nuclear Cardiology. Background: The objective of this study was to measure myocardial blood flow (MBF) in humans using99mTc-tetrofosmin and dynamic single-photon emission computed tomography (SPECT). Methods: Dynamic SPECT using99mTc-tetrofosmin and dynamic positron emission tomography (PET) was performed on a group of 16 patients. The SPECT data were reconstructed using a 4D-spatiotemporal iterative reconstruction method. The data corresponding to 9 patients were used to determine the flow-extraction curve for99mTc-tefrofosmin while data from the remaining 7 patients were used for method validation. The nonlinear tracer correction parameters A and B for99mTc-tefrofosmin were estimated for the 9 patients by fitting the flow-extraction curve K1=F(1-Aexp(-BF)) for K1values estimated with99mTc-tefrofosmin using SPECT and MBF values estimated with13N-NH3using PET. These parameters were then used to calculate MBF and coronary flow reserve (CFR) in three coronary territories (LAD, RCA, and LCX) using SPECT for an independent cohort of 7 patients. The results were then compared with that estimated with13N-NH3PET. The flow-dependent permeability surface-area product (PS) for99mTc-tefrofosmin was also estimated. Results: The estimated flow-extraction parameters for99mTc-tefrofosmin were found to be A = 0.91 ± 0.11, B = 0.34 ± 0.20 (R2 = 0.49). The range of MBF in LAD, RCA, and LCX was 0.44-3.81 mL/min/g. The MBF between PET and SPECT in the group of independent cohort of 7 patients showed statistically significant correlation, r = 0.71 (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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