Association of maternal diet, micronutrient status, and milk volume with milk micronutrient concentrations in Indonesian mothers at 2 and 5 months postpartum
| Autor: | Gibson, Rosalind S, Rahmannia, Sofa, Diana, Aly, Leong, Claudia, Haszard, Jillian J, Hampel, Daniela, Reid, Malcolm, Erhardt, Juergen, Suryanto, Aghnia Husnayiani, Sofiah, Wina Nur, Fathonah, Annisha, Shahab-Ferdows, Setareh, Allen, Lindsay H, Houghton, Lisa A |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
and promotion of well-being maternal biomarkers maternal micronutrient deficits Reproductive health and childbirth Medical and Health Sciences maternal micronutrient intakes Engineering Pregnancy Clinical Research Humans Micronutrients temporal changes in human milk nutrient concentrations 3.3 Nutrition and chemoprevention Nutrition Pediatric human milk volume Nutrition & Dietetics Prevention Postpartum Period human milk micronutrient concentrations Prevention of disease and conditions Diet Milk Good Health and Well Being Female Human |
| Zdroj: | The American journal of clinical nutrition, vol 112, iss 4 |
| Popis: | BackgroundMaternal micronutrient deficits during preconception and pregnancy may persist during lactation and compromise human milk composition.ObjectiveWe measured micronutrient concentrations in human milk and investigated their association with maternal micronutrient intakes, status, and milk volume.MethodsInfant milk intake (measured via a deuterium dose-to-mother technique), milk micronutrient and fat concentrations, and maternal micronutrient intakes were assessed at 2 and 5mo postpartum in 212 Indonesian lactating mother-infant pairs. Maternal hemoglobin, ferritin, transferrin receptors, retinol binding protein (RBP), zinc, selenium, and vitamin B-12 were measured at 5 mo (n=163). Multivariate or mixed effects regression examined associations of milk micronutrient concentrations with maternal micronutrient intakes, status, and milk volume.ResultsPrevalence of anemia (15%), and iron (15% based on body iron), selenium (2.5%), and vitamin B-12 deficiency (0%) were low compared with deficiencies of zinc (60%) and vitamin A (34%). The prevalence of inadequate intakes was >50% for 7 micronutrients at 2 and 5 mo. Median milk concentrations for most micronutrients were below reference values, and nearly all declined between 2 and 5 mo postpartum and were not associated substantially with milk volume (except for β-carotene, α-carotene, and β-cryptoxanthin). At 5 mo postpartum, associations between maternal micronutrient status and corresponding milk concentrations reported as mean percentage difference in human milk concentration for each unit higher maternal biomarker were significant for hemoglobin (1.9%), iron biomarkers (ranging from 0.4 to 7%), RBP (35%), selenium (70%), and vitamin B-12 (0.1%), yet for maternal intakes only a positive association with β-carotene existed.ConclusionsMost milk micronutrient concentrations declined during lactation, independent of changes in human milk production, and few were associated with maternal micronutrient intakes. The significant associations between maternal biomarkers and milk micronutrient concentrations at 5 mo warrant further study to investigate whether the declines in milk micronutrients are linked to shifts in maternal status. |
| Databáze: | OpenAIRE |
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