Pathogenic Mitochondrial Dysfunction and Metabolic Abnormalities
| Autor: | Moos, Walter H, Faller, Douglas V, Glavas, Ioannis P, Harpp, David N, Kamperi, Natalia, Kanara, Iphigenia, Kodukula, Krishna, Mavrakis, Anastasios N, Pernokas, Julie, Pernokas, Mark, Pinkert, Carl A, Powers, Whitney R, Steliou, Kosta, Tamvakopoulos, Constantin, Vavvas, Demetrios G, Zamboni, Robert J, Sampani, Konstantina |
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| Rok vydání: | 2021 |
| Předmět: |
Physiological networks
Pathogenesis and pathogenic drivers Mitochondrial Diseases Biochemical pathways Diseases Pathogenesis Therapeutics Neurodegenerative Metabolic Diseases Genetics Homeostasis Animals Humans 2.1 Biological and endogenous factors Pharmacology & Pharmacy Aetiology Metabolic and endocrine Nutrition Healthy Disorders COVID-19 Reprogramming Neurodegenerative Diseases Pharmacology and Pharmaceutical Sciences Metabolic abnormalities Diet Mitochondria Oxidative Stress Dysfunction Biochemistry and Cell Biology Energy Metabolism |
| Popis: | Herein we trace links between biochemical pathways, pathogenesis, and metabolic diseases to set the stage for new therapeutic advances. Cellular and acellular microorganisms including bacteria and viruses are primary pathogenic drivers that cause disease. Missing from this statement are subcellular compartments, importantly mitochondria, which can be pathogenic by themselves, also serving as key metabolic disease intermediaries. The breakdown of food molecules provides chemical energy to power cellular processes, with mitochondria as powerhouses and ATP as the principal energy carrying molecule. Most animal cell ATP is produced by mitochondrial synthase; its central role in metabolism has been known for >80 years. Metabolic disorders involving many organ systems are prevalent in all age groups. Progressive pathogenic mitochondrial dysfunction is a hallmark of genetic mitochondrial diseases, the most common phenotypic expression of inherited metabolic disorders. Confluent genetic, metabolic, and mitochondrial axes surface in diabetes, heart failure, neurodegenerative disease, and even in the ongoing coronavirus pandemic. |
| Databáze: | OpenAIRE |
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