IgG intrathecal synthesis in HIV-associated neurocognitive disorder (HAND) according to the HIV-1 subtypes and pattern of HIV RNA in CNS and plasma compartments
| Autor: | De Almeida, Sergio M, Rotta, Indianara, Tang, Bin, Vaida, Florin, Letendre, Scott, Ellis, Ronald J, HNRC Group |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Discordance Pediatric AIDS AIDS Dementia Complex Immunology HIV Infections HAND Spinal Puncture Clinical Research Genetics Humans Viral Subtypes Pediatric Neurology & Neurosurgery HNRC Group Neurosciences Middle Aged IgG synthesis Cross-Sectional Studies Cerebrospinal fluid Mental Health Infectious Diseases Immunoglobulin G HIV-1 RNA HIV/AIDS Female Infection Biomarkers |
| Popis: | We hypothesized that humoral immunity stimulation in the CNS in HIV-1C patients would be lower than that in HIV-1B due to a defective Tat chemokine dimotif (C30C31) that might influence cellular trafficking and CNS inflammation. Sixty-eight paired CSF and blood samples from people with HIV (PWH), free of CNS opportunistic infections, were included, HIV-1B (n=27), HIV-1C (n=26), and HIV negative (n=25). IgG intrathecal synthesis was assayed using quantitative and qualitative methods. IgG oligoclonal bands (OCB) in CSF were observed in 51% of PWH, comparable between HIV-1B and HIV-1C, as well as the medians of IgG intrathecal synthesis formulas. The group with HIV infection aviremic in CSF and blood showed 75% of OCB. There was a poor positive correlation between the IgG quotient and GDS. The impact of HIV-1 on IgG intrathecal production was not subtype dependent. Low-grade CNS intrathecal IgG production persists in HIV CNS infection even in PWH with CSF and blood HIV RNA controlled. |
| Databáze: | OpenAIRE |
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