Clonal hematopoiesis associated with epigenetic aging and clinical outcomes
| Autor: | Nachun, Daniel, Lu, Ake T, Bick, Alexander G, Natarajan, Pradeep, Weinstock, Joshua, Szeto, Mindy D, Kathiresan, Sekar, Abecasis, Goncalo, Taylor, Kent D, Guo, Xiuqing, Tracy, Russ, Durda, Peter, Liu, Yongmei, Johnson, Craig, Rich, Stephen S, Van Den Berg, David, Laurie, Cecilia, Blackwell, Tom, Papanicolaou, George J, Correa, Adolfo, Raffield, Laura M, Johnson, Andrew D, Murabito, Joanne, Manson, JoAnn E, Desai, Pinkal, Kooperberg, Charles, Assimes, Themistocles L, Levy, Daniel, Rotter, Jerome I, Reiner, Alex P, Whitsel, Eric A, Wilson, James G, Horvath, Steve, Jaiswal, Siddhartha, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium |
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| Rok vydání: | 2021 |
| Předmět: |
Epigenomics
Aging Human Genome heart disease Biological Sciences Cardiovascular Medical and Health Sciences NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Treatment Outcome Good Health and Well Being Risk Factors clonal hematopoiesis Genetics Humans 2.1 Biological and endogenous factors Patient Safety Aetiology Developmental Biology |
| Zdroj: | Aging cell, vol 20, iss 6 |
| Popis: | Clonal hematopoiesis of indeterminate potential (CHIP) is a common precursor state for blood cancers that most frequently occurs due to mutations in the DNA-methylation modifying enzymes DNMT3A or TET2. We used DNA-methylation array and whole-genome sequencing data from four cohorts together comprising 5522 persons to study the association between CHIP, epigenetic clocks, and health outcomes. CHIP was strongly associated with epigenetic age acceleration, defined as the residual after regressing epigenetic clock age on chronological age, in several clocks, ranging from 1.31years (GrimAge, p0 in both Hannum and GrimAge (referred to as AgeAccelHG+). This group was at high risk of all-cause mortality (hazard ratio 2.90, p |
| Databáze: | OpenAIRE |
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