Real-time magnetic resonance imaging technique for determining left ventricle pressure-volume loops
| Autor: | Witschey, Walter RT, Contijoch, Francisco, McGarvey, Jeremy R, Ferrari, Victor A, Hansen, Michael S, Lee, Madonna E, Takebayashi, Satoshi, Aoki, Chikashi, Chirinos, Julio A, Yushkevich, Paul A, Gorman, Joseph H, Pilla, James J, Gorman, Robert C |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Swine Animal Heart Ventricles Left Respiratory System Clinical Sciences Stroke Volume Cardiorespiratory Medicine and Haematology Magnetic Resonance Imaging Sensitivity and Specificity Myocardial Contraction Random Allocation Computer-Assisted Cine Heart Rate Disease Models Ventricular Dysfunction Ventricular Pressure Animals Ventricular Function Cardiac Output Image Interpretation |
| Zdroj: | The Annals of thoracic surgery, vol 97, iss 5 |
| Popis: | BackgroundRapid determination of the left ventricular (LV) pressure-volume (PV) relationship as loading conditions are varied is the gold standard for assessment of LV function. Cine magnetic resonance imaging (MRI) does not have sufficient spatiotemporal resolution to assess beat-to-beat changes of the LV PV relationship required to measure the LV end-systolic elastance (EES) or preload-recruitable stroke work (PRSW). Our aim was to investigate real-time MRI and semiautomated LV measurement of LV volume to measure PV relations in large animals under normal and inotropically stressed physiologic conditions.MethodsWe determined that PV relationships could be accurately measured using an image exposure time Tex less than 100 ms and frame rate Tfr less than 50 ms at elevated heart rates (∼140 beats per minute) using a golden angle radial MRI k-space trajectory and active contour segmentation.ResultsWith an optimized exposure time (Tex=95 ms and frame rate Tfr=2.8 ms), we found that there was no significant difference between cine and real-time MRI at rest in end-diastolic volume, end-systolic volume, ejection fraction, stroke volume, or cardiac output (n=5, p |
| Databáze: | OpenAIRE |
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