| Autor: |
Malhotra, Deepali, Linehan, Jonathan L, Dileepan, Thamotharampillai, Lee, You Jeong, Purtha, Whitney E, Lu, Jennifer V, Nelson, Ryan W, Fife, Brian T, Orr, Harry T, Anderson, Mark S, Hogquist, Kristin A, Jenkins, Marc K |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Nature immunology, vol 17, iss 2 |
| Popis: |
Studies of repertoires of mouse monoclonal CD4(+) T cells have revealed several mechanisms of self-tolerance; however, which mechanisms operate in normal repertoires is unclear. Here we studied polyclonal CD4(+) T cells specific for green fluorescent protein expressed in various organs, which allowed us to determine the effects of specific expression patterns on the same epitope-specific T cells. Peptides presented uniformly by thymic antigen-presenting cells were tolerated by clonal deletion, whereas peptides excluded from the thymus were ignored. Peptides with limited thymic expression induced partial clonal deletion and impaired effector T cell potential but enhanced regulatory T cell potential. These mechanisms were also active for T cell populations specific for endogenously expressed self antigens. Thus, the immunotolerance of polyclonal CD4(+) T cells was maintained by distinct mechanisms, according to self-peptide expression patterns. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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