Genome-wide association study for age-related hearing loss (AHL) in the mouse: a meta-analysis
| Autor: | Ohmen, Jeffrey, Kang, Eun Yong, Li, Xin, Joo, Jong Wha, Hormozdiari, Farhad, Zheng, Qing Yin, Davis, Richard C, Lusis, Aldons J, Eskin, Eleazar, Friedman, Rick A |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Aging Quantitative Trait Loci Clinical Sciences Sensorineural Mice Genetics Animals Humans 2.1 Biological and endogenous factors mouse models Aetiology Hearing Loss Evoked Potentials Auditory Probability genome-wide association study Animal Prevention Human Genome Neurosciences meta-analysis age-related hearing loss random-effects model Otorhinolaryngology Disease Models Female Brain Stem |
| Zdroj: | Journal of the Association for Research in Otolaryngology : JARO, vol 15, iss 3 |
| Popis: | Age-related hearing loss (AHL) is characterized by a symmetric sensorineural hearing loss primarily in high frequencies and individuals have different levels of susceptibility to AHL. Heritability studies have shown that the sources of this variance are both genetic and environmental, with approximately half of the variance attributable to hereditary factors as reported by Huag and Tang (Eur Arch Otorhinolaryngol 267(8):1179-1191, 2010). Only a limited number of large-scale association studies for AHL have been undertaken in humans, to date. An alternate and complementary approach to these human studies is through the use of mouse models. Advantages of mouse models include that the environment can be more carefully controlled, measurements can be replicated in genetically identical animals, and the proportion of the variability explained by genetic variation is increased. Complex traits in mouse strains have been shown to have higher heritability and genetic loci often have stronger effects on the trait compared to humans. Motivated by these advantages, we have performed the first genome-wide association study of its kind in the mouse by combining several data sets in a meta-analysis to identify loci associated with age-related hearing loss. We identified five genome-wide significant loci ( |
| Databáze: | OpenAIRE |
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