Constrained bithiazoles: Small molecule correctors of defective δf508-CFTR protein trafficking

Autor: Verkman, Alan, Coffman, KC, Nguyen, HH, Phuan, PW, Hudson, BM, Yu, GJ, Bagdasarian, AL, Montgomery, D, Lodewyk, MW, Yang, B, Yoo, CL
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Verkman, Alan; Coffman, KC; Nguyen, HH; Phuan, PW; Hudson, BM; Yu, GJ; et al.(2014). Constrained bithiazoles: Small molecule correctors of defective δf508-CFTR protein trafficking. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4gh0h4d7
Popis: Conformationally constrained bithiazoles were previously found to have improved efficacy over nonconstrained bithiazoles for correction of defective cellular processing of the δF508 mutant cystic fibrosis transmembrane conductance regulator (CFTR) protein.
Databáze: OpenAIRE