Impact of a novel prognostic model, hematopoietic cell transplant-composite risk (HCT-CR), on allogeneic transplant outcomes in patients with acute myeloid leukemia and myelodysplastic syndrome
| Autor: | Kongtim, Piyanuch, Parmar, Simrit, Milton, Denái R, Perez, Jorge Miguel Ramos, Rondon, Gabriela, Chen, Julianne, Chilkulwar, Abhishek R, Al-Atrash, Gheath, Alousi, Amin, Andersson, Borje S, Im, Jin S, Hosing, Chitra M, Bashir, Qaiser, Khouri, Issa, Kebriaei, Partow, Oran, Betul, Popat, Uday, Champlin, Richard, Ciurea, Stefan O |
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| Rok vydání: | 2019 |
| Předmět: |
Homologous
Adult Male Myeloid Pediatric Research Initiative Transplantation Conditioning Adolescent Childhood Leukemia Pediatric Cancer Clinical Sciences Oncology and Carcinogenesis Immunology Acute Young Adult Rare Diseases Clinical Research Stem Cell Research - Nonembryonic - Human Humans Aged Cancer Pediatric Transplantation Leukemia Hematopoietic Stem Cell Transplantation Hematology Middle Aged Prognosis Stem Cell Research Survival Rate Treatment Outcome Myelodysplastic Syndromes Female |
| Zdroj: | Bone marrow transplantation, vol 54, iss 6 |
| Popis: | Outcomes after allogeneic stem-cell transplantation (AHSCT) are influenced by both disease- and patient-related factors. Here, we developed a novel prognostic model, hematopoietic cell transplant-composite risk (HCT-CR), by combining the refined disease risk index (DRI-R) and hematopoietic stem-cell transplant comorbidity/age index (HCT-CI/Age) to predict post-transplant survival for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). The analysis included 942 AML/MDS patients treated with AHSCT. Patients were stratified into 4 HCT-CR risk groups: Low-risk-patients with low/intermediate DRI-R and HCT-CI/Age ≤3 (N = 272); Intermediate-risk-patients with low/intermediate DRI-R and HCT-CI/Age >3 (N = 168); High-risk-patients with high/very high DRI-R and HCT-CI/Age ≤3 (N = 284); and Very high-risk-patients with high/very high DRI-R and HCT-CI/Age >3 (N = 184). Compared with the low-risk group, intermediate, high, and very high-risk groups had a significantly increased risk of death [adjusted HR of 1.37 (P |
| Databáze: | OpenAIRE |
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