| Autor: |
Guan, Meijian, Keaton, Jacob M, Dimitrov, Latchezar, Hicks, Pamela J, Xu, Jianzhao, Palmer, Nicholette D, Ma, Lijun, Das, Swapan K, Chen, Yii-Der I, Coresh, Josef, Fornage, Myriam, Franceschini, Nora, Kramer, Holly, Langefeld, Carl D, Mychaleckyj, Josyf C, Parekh, Rulan S, Post, Wendy S, Rasmussen-Torvik, Laura J, Rich, Stephen S, Rotter, Jerome I, Sedor, John R, Thornley-Brown, Denyse, Tin, Adrienne, Wilson, James G, Freedman, Barry I, Bowden, Donald W, Ng, Maggie CY, FIND Consortium |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Human genomics, vol 13, iss 1 |
| Popis: |
BackgroundEnd-stage kidney disease (ESKD) is a significant public health concern disproportionately affecting African Americans (AAs). Type 2 diabetes (T2D) is the leading cause of ESKD in the USA, and efforts to uncover genetic susceptibility to diabetic kidney disease (DKD) have had limited success. A prior genome-wide association study (GWAS) in AAs with T2D-ESKD was expanded with additional AA cases and controls and genotypes imputed to the higher density 1000 Genomes reference panel. The discovery analysis included 3432 T2D-ESKD cases and 6977 non-diabetic non-nephropathy controls (N = 10,409), followed by a discrimination analysis in 2756 T2D non-nephropathy controls to exclude T2D-associated variants.ResultsSix independent variants located in or near RND3/RBM43, SLITRK3, ENPP7, GNG7, and APOL1 achieved genome-wide significant association (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
