In Children With Nonalcoholic Fatty Liver Disease, Zone 1 Steatosis Is Associated With Advanced Fibrosis

Autor: Africa, JA, Behling, CA, Brunt, EM, Zhang, N, Luo, Y, Wells, A, Hou, J, Belt, PH, Kohil, R, Lavine, JE, Molleston, JP, Newton, KP, Whitington, PF, Schwimmer, JB, Abrams, SH, Barlow, S, Himes, R, Krisnamurthy, R, Maldonado, L, Mahabir, R, Carr, A, Bernstein, K, Bramlage, K, Cecil, K, DeVore, S, Kohli, R, Lake, K, Podberesky, D, Towbin, A, Xanthakos, S, Behr, G, Lefkowitch, JH, Mencin, A, Reynoso, E, Alazraki, A, Cleeton, R, Cordero, M, Hernandez, A, Karpen, S, Munos, JC, Raviele, N, Vos, M, Bozic, M, Cummings, OW, Klipsch, A, Ragozzino, E, Sandrasegaran, K, Subbarao, G, Walker, L, Kafka, K, Scheimann, A, Ito, J, Fishbein, MH, Mohammad, S, Rigsby, C, Sharda, L, Cattoor, T, Derdoy, J, Freebersyser, J, Jain, A, King, D, Lai, J, Osmack, P, Siegner, J, Stewart, S, Torretta, S, Wriston, K, Baker, SS, Lopez-Graham, D, Williams, S, Zhu, L, Awai, H, Behling, C, Bross, C, Collins, J, Durelle, J, Harlow, K, Middleton, M, Paiz, M, Sirlin, C, Ugalde-Nicalo, P, Villarreal, MD, Aouizerat, B, Courtier, J, Ferrell, LD, Feier, N, Gill, R, Langlois, C
Jazyk: angličtina
Rok vydání: 2018
Zdroj: Africa, JA; Behling, CA; Brunt, EM; Zhang, N; Luo, Y; Wells, A; et al.(2018). In Children With Nonalcoholic Fatty Liver Disease, Zone 1 Steatosis Is Associated With Advanced Fibrosis. Clinical Gastroenterology and Hepatology, 16(3), 438-446.e1. doi: 10.1016/j.cgh.2017.02.030. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2g75d87d
Popis: © 2018 AGA Institute Background & Aims: Focal zone 1 steatosis, although rare in adults with nonalcoholic fatty liver disease (NAFLD), does occur in children with NAFLD. We investigated whether focal zone 1 steatosis and focal zone 3 steatosis are distinct subphenotypes of pediatric NAFLD. We aimed to determine associations between the zonality of steatosis and demographic, clinical, and histologic features in children with NAFLD. Methods: We performed a cross-sectional study of baseline data from 813 children (age
Databáze: OpenAIRE