Cyclooxygenase-2 expression is related to nuclear grade in ductal carcinoma in situ and is increased in its normal adjacent epithelium
| Autor: | Shim, Veronica, Gauthier, Mona L, Sudilovsky, Daniel, Mantei, Kristin, Chew, Karen L, Moore, Dan H, Cha, Imok, Tlsty, Thea D, Esserman, Laura J |
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| Rok vydání: | 2003 |
| Předmět: |
Cell Nucleus
Adult Non-NASA Center Carcinoma Oncology and Carcinogenesis Membrane Proteins Epithelial Cells Breast Neoplasms Middle Aged Immunohistochemistry Up-Regulation Isoenzymes NASA Discipline Radiation Health Prostaglandin-Endoperoxide Synthases Cyclooxygenase 2 Ductal Humans 2.1 Biological and endogenous factors Female Breast Oncology & Carcinogenesis Aetiology Carcinoma in Situ Aged Cancer |
| Zdroj: | Cancer research, vol 63, iss 10 |
| Popis: | Cyclooxygenase-2 (COX-2) is emerging as an important cancer biomarker and is now an experimental target for solid tumor treatment.However, no study has exclusively focused on COX-2 expression in early lesions such as ductal carcinoma in situ (DCIS). We examined COX-2 expression by immunohistochemistry in 46 cases of women undergoing surgical resection for DCIS. We found that COX-2 expression was detected in 85% of all DCIS specimens, with increased COX-2 staining correlating with higher nuclear grade. Strikingly, COX-2 staining intensity in the normal adjacent epithelium was stronger than in the DCIS lesion itself. Our observations demonstrate that COX-2 is up-regulated in the normal adjacent epithelium and supports the hypothesis that the surrounding epithelial tissue is part of the disease process in DCIS. |
| Databáze: | OpenAIRE |
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