MSC morphofunctional programming for improved orthopaedic implantation outcomes
| Autor: | Fonseca, Francisca Rocha Melo, Pinto, Inês Mendes, Gasik, Michael, Silva, Filipe Samuel, Miranda, Maria Georgina Macedo |
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| Přispěvatelé: | Universidade do Minho |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
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| Popis: | Orthopaedic interventions have risen over the last two decades and are expected to increase due to aging population. Despite advances in orthopaedic implant research, prosthetic failure is often observed, leading to implant replacement. Impaired implant fixation is mainly due to an improper mechanical stimulation at the interface between natural bone and the implant, often composed of Ti6Al4V. At the cellular level, bone remodelling is correlated to the osteoblastic differentiation dynamics of bone-marrow derived mesenchymal stem cells (MSC) in response to changes in their environment. Although the importance of the cytoskeleton as a major mechanotransducer in MSC is widely accepted, it remains elusive how mechanochemical signals regulate MSC differentiation in their interaction with bone and implants. This work was supported by FCT (Fundação para a Ciência e a Tecnologia) through the grants SFRH/BD/141056/2018, COVID/BD/152996/2022 and UMINHO/BID/2023/04 and the projects PTDC/EME-EME/1442/2020, POCI-01-0145-FEDER-030498, UIDB/04436/2020 and UIDP/04436/2020. In addition, this work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020, financed by national funds through the FCT/MCTES (PIDDAC). |
| Databáze: | OpenAIRE |
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