Emerging challenges in assessing bio-based nanosystems’ behaviour under in vitro digestion focused on food applications – a critical view and future perspectives
| Autor: | Madalena, Daniel Alexandre Silva, Fernandes, Jean Michel, Avelar, Zita Sofia Barbosa, Gonçalves, Raquel Filipa Silva, Ramos, Óscar L., Vicente, A. A., Pinheiro, A. C. |
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| Přispěvatelé: | Universidade do Minho |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
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| Popis: | In Press, Journal Pre-proof ; Available online 29 May 2022 The current consumers demand for high quality food products together with the growing awareness regarding the link between health and nutrition has led to the development of novel food products with added functionality. Such functionality can be modulated by adding bio-based nanosystems that can improve the bioaccessibility of bioactive compounds and facilitate nutrient absorption. However, these functional properties can be significantly affected by the adverse conditions (e.g., low pH, presence of enzymes, salts) of the gastrointestinal tract. As such, understanding the behaviour of such delivery systems under digestion conditions is of utmost importance and several analytical tools and in vitro digestion models have been used for this purpose. This review summarizes the latest updates on nanosystems performance under in vitro digestion and provides critical insights related to important and complementary analytical tools (e.g., rheology, Raman spectroscopy, x-ray scattering) used to assess their performance throughout digestion. Furthermore, the most prominent and frequent challenges associated with such in vitro analyses are also described, together with the current trends regarding the development of in vitro digestion models and some considerations that should be undertaken for their validation. Efforts must be made towards developing reliable and standard in vitro digestion models that use sophisticated analytical techniques to further expand the knowledge regarding nanosystems behaviour under in vitro digestion conditions. Daniel A. Madalena, Jean M. Fernandes, Zita S. Avelar and Raquel F. Gonçalves acknowledge the Foundation for Science and Technology (FCT) for their fellowship (SFRH/BD/129127/2017, SFRH/BD/147286/2019, SFRH/BD/146347/2019, SFRH/BD/140182/2018, respectively). This work was supported by Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit and the I&D&I project AgriFood XXI with the operation number NORTE-01-0145-FEDER-000041, co-funded by the Fundo Europeu de Desenvolvimento Regional (FEDER) through NORTE 2020 (Programa Operacional Regional do Norte 2014/2020). info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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