Synthesis and photorelease studies from model quinolone conjugates

Autor: Domingues, B. B., Felgueiras, C. F. F., Ferreira, M. A. L., Pereira, A. S. R., Gonçalves, M. Sameiro T., Costa, Susana P. G., Fonseca, Andrea Susana Cabral da
Přispěvatelé: Universidade do Minho
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Popis: Comunicação em painel P1.24.
We present the synthesis and the photolytic release at longer wavelengths of phenylalanine, acting as a model amino acid, from conjugates bearing a methoxylated quinolone 2a,b. The photolytic study was carried out by irradiation at 300, 350 and 419 nm in a methanol/HEPES buffer solution (80:20). Monitoring of the photolysis of 2a,b and consequent release of N-benzyloxycarbonylphenylalanine was carried out by HPLC-UV detection and kinetic data was obtained.
Databáze: OpenAIRE