Dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles enhances bone formation in vivo
| Autor: | Oliveira, J. M., Sousa, R. A., Kotobuki, N., Malafaya, P. B., Hirose, M., Mano, J. F., Reis, R. L., Ohgushi, H. |
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| Přispěvatelé: | Universidade do Minho |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: | |
| Popis: | [Excerpt] Dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles, CMC/PAMAM-Dex were successfully synthesized to find applications as a controlled system of relevant molecules in Bone Tissue Engineering. These are aimed at modulatingtheproliferation anddifferentiationofstem cells,both invitro and in vivo. In previous work, we have demonstrated that CMC/ PAMAM-Dex nanoparticles are internalized with high efficiency by different cell types, namely osteoblastic-cells, SaOs-2 and rat bone marrow stromal cells, RBMSCs. The biocompatibility of HA and SPCL scaffolds was also assessed by means of seeding RBMSCs onto the materials and performing a luminescent cell viability assay, after 24 and 72hrs. [...] info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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