| Popis: |
This thesis investigates the impact of selenium (Se) supplementation on health and well-being, including thyroid function, male reproductive health, and gut microbiome. It hypothesizes that an adequate supply of dietary Se in its optimal chemical form and dosage could have far-reaching benefits for overall health. The study had four objectives: (1) assess thyroid function by comparing hormone levels and enzymes, (2) investigate Se supplementation effects on male reproductive health, including sperm count, motility, and vitality, (3) characterize testicular structure changes and the presence of selenoproteins GPx1/4, and (4) differentiate gut microbiome differences in mice fed Se-supplemented diets versus standard chow. The main findings are: (1) the most effective outcomes were observed with Nanoparticle Selenium (NanoSe) in the short-term, but more research is needed to understand its potency long-term, (2) various forms of Se, like Sodium Selenite (NaSe), Methyl-selenocysteine (Met), and NanoSe, can improve male reproductive parameters, and (3) NanoSe most effectively alters the microbiome composition, while Diphenyl Deiselenide (DDS) shows distinct differences in metabolism and biochemistry. In conclusion, the study suggests that adequate dietary Se in its optimal chemical form and dosage can have significant health benefits. The results highlight the need for further research to understand the long-term safety and efficacy of Se supplementation. |
