Separation of isomeric disaccharides by traveling wave ion mobility mass spectrometry using CO2 as drift gas

Autor: Fasciotti, Maira, Sanvido, Gustavo B., Santos, Vanessa G., Lalli, Priscila M., McCullagh, Michael, de Sa, Gilberto F., Daroda, Romeu J., Peter, Martin G., Eberlin, Marcos N.
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Popis: The use of CO2 as a massive and polarizable drift gas is shown to greatly improve peak-to-peak resolution (Rp-p), as compared with N2, for the separation of disaccharides in a Synapt G2 traveling wave ion mobility cell. Near or baseline Rp-p was achieved for three pairs of sodiated molecules of disaccharide isomers, that is, cellobiose and sucrose (Rp-p?=?0.76), maltose and sucrose (Rp-p?=?1.04), and maltose and lactose (Rp-p?=?0.74). Ion mobility mass spectrometry using CO2 as the drift gas offers therefore an attractive alternative for fast and efficient separation of isomeric disaccharides.
Databáze: OpenAIRE