| Autor: |
Schenk, Matthew, Eichelmann, Fabian (Dr. rer. nat.), Schulze, Matthias Bernd (Prof. Dr.), Rudovich, Natalia, Pfeiffer, Andreas F. H., di Giuseppe, Romina, Böing, Heiner (Prof. Dr.), Aleksandrova, Krasimira (Dr. habil.) |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Popis: |
Aim: Assessment of the feasibility and reliability of immune-inflammatory biomarker measurements. Methods: The following biomarkers were assessed in 207 predominantly healthy participants at baseline and after 4 months: MMF, TGF-beta, suPAR and clusterin. Results: Intraclass correlation coefficients (95% CIs) ranged from good for TGF-beta (0.75 [95% CI: 0.33-0.90]) to excellent for MMF (0.81 [95% CI: 0.64-0.90]), clusterin (0.83 [95% CI: 0.78-0.87]) and suPAR (0.91 [95% CI: 0.88-0.93]). Measurement of TGF-beta was challenged by the large number of values below the detection limit. Conclusion: Single measurements of suPAR, clusterin and MMF could serve as feasible and reliable biomarkers of immune-inflammatory pathways in biomedical research. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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