Maternal fine particulate matter exposure, polymorphism in xenobiotic-metabolizing genes and offspring birth weight.: Air pollution, genes and birthweight
| Autor: | Slama, Rémy, Gräbsch, Carolin, Lepeule, Johanna, Siroux, Valérie, Cyrys, Josef, Sausenthaler, Stefanie, Herbarth, Olf, Bauer, Mario, Borte, Michael, Wichmann, H-Erich, Heinrich, Joachim |
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| Přispěvatelé: | Equipe avenir 'Environmental Epidemiology Applied to Fecundity and Reproduction', Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of environmental immunology, Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Center For Narcolepsy, Stanford University, Environment Science Center, Universität Augsburg [Augsburg], Dept. Environmental Medicine and Hygiene, Universität Leipzig [Leipzig], Dept. of Paediatrics.8, Municipal Hospital Saint Georg-Universität Leipzig [Leipzig] |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
MESH: Smoking
MESH: Mutation MESH: Fetal Growth Retardation Air pollution MESH: Cytochrome P-450 CYP2D6 Smoking Genetic MESH: Child MESH: Polymorphism Genetic Birth Weight Polymorphism MESH: Birth Weight MESH: Maternal Exposure MESH: Cohort Studies MESH: Germany MESH: Glutathione S-Transferase pi MESH: Genetic Association Studies MESH: Glutathione Transferase MESH: Humans MESH: Adult MESH: Metabolic Detoxication Drug MESH: Particulate Matter MESH: Vehicle Emissions MESH: Young Adult Particulate Matter [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie MESH: Female Passive Smoking |
| Zdroj: | Reproductive Toxicology Reproductive Toxicology, Elsevier, 2010, 30 (4), pp.600-12. ⟨10.1016/j.reprotox.2010.07.001⟩ |
| ISSN: | 0890-6238 |
| DOI: | 10.1016/j.reprotox.2010.07.001⟩ |
| Popis: | International audience; We aimed to describe if polymorphisms in xenobiotics-metabolizing genes modify the effect of maternal exposure to fine particulate matter (PM(2.5)) on offspring birth weight. Among newborns from LISA cohort, we tested if polymorphisms of GSTT1, GSTP1, GSTM1, and CYP2D6 genes modified the effect measure of PM(2.5) on term birth weight. Subsequently, we tested if polymorphisms modified the effect of other exposure factors with possibly similar pathways of action (active or passive smoking). PM (2.5) exposure above the median value (reference, below) was associated with birth weight changes by 76 g in the homozygous wild type genotype (n=161), -90 g in the heterozygous genotype (n=154) and -168 g in children with GSTP1 *1B/*1B mutant genotype (n=39, interaction test, p=0.05). No effect measure modification with PM(2.5) was detected for GSTT1, GSTM1 or CYP2D6 polymorphisms (p≥ 0.12). No effect measure modification with GSTP1 polymorphism was detected for active (p=0.71) nor for passive smoking effects on birth weight (p=0.13). |
| Databáze: | OpenAIRE |
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