Transoesophageal ultrasound applicator for sector-based thermal ablation: first in vivo experiments
| Autor: | Melodelima, David, Lafon, Cyril, Prat, Frédéric, Theillère, Yves, Arefiev, Alexei, Cathignol, Dominique |
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| Přispěvatelé: | Applications des ultrasons à la thérapie, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was partially supported by a grant from the French Ministry of National Education, Research, and Technology (MENRT), grant N° 2000/102 (ACI telemedecine and technologies) and by a grant of the Agency for Research on Cancer (ARC), grant N° 4443. |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
MESH: Catheter Ablation
MESH: Echocardiography Transesophageal coagulation necrosis intraductal therapy MESH: Ultrasonic Therapy MESH: Research Support Non-U.S. Gov't MESH: Echocardiography Transesop MESH: Male thermal ablation plane transducer high intensity ultrasound Ultrasound MESH: Esophageal Neoplasms MESH: Animals MESH: Palliative Care [SDV.IB]Life Sciences [q-bio]/Bioengineering sector-based MESH: Swine MESH: Equipment Design MESH: Transducers |
| Zdroj: | Ultrasound in Medicine & Biology Ultrasound in Medicine & Biology, Elsevier, 2003, 29 (2), pp.285-91. ⟨10.1016/S0301-5629(02)00701-9⟩ |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/S0301-5629(02)00701-9⟩ |
| Popis: | New curative and palliative treatments must be proposed to respond to the bad long-term prognosis of oesophageal cancers. It has been demonstrated that high intensity ultrasound (US) can induce rapid, complete and well-defined coagulation necrosis. For the treatment of this cancer, we designed an applicator that uses an intraductal approach. The active part is an air-backed plane transducer. It has an external water-cooling system and operates at 10 MHz. Ex vivo experiments conducted on pig liver demonstrated the ability of this applicator to generate, by rotating the transducer, circular or sector-based coagulation necroses at predetermined depths up to 13 mm, with an excellent angular precision. The treatment of sector-based oesophageal tumours may be critical, where both malignant and healthy tissues are covered by the US beam. Thus, in vivo trials were conducted on five healthy pig oesophaguses to determine the maximal thermal dose that will not induce a perforation of the oesophagus or surrounding tissues. From the results of previous studies, this dose is high enough to treat pathological tissues. These promising results indicate that this US system represents a safe and effective tool for the clinical treatment of oesophageal tumours. |
| Databáze: | OpenAIRE |
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