Natural IgE production in the absence of MHC Class II cognate help
| Autor: | Harris, N. L., McCoy, K. D., Diener, P., Hatak, S., Odermatt, B., Hangartner, L., Senn, B. M., Marsland, B. J., Geuking, M. B., Hengartner, H., Macpherson, A. J., Zinkernagel, R. M. |
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| Předmět: |
Mice
Inbred C57BL T-Lymphocytes Regulatory/physiology Mice Mice Inbred BALB C Mice Inbred ICR Mast Cells/physiology Antibodies Helminth/biosynthesis Interleukin-4/physiology T-Lymphocytes/physiology B-Lymphocytes/physiology Animals Histocompatibility Antigens Class II/*physiology Immunoglobulin E/*biosynthesis |
| Popis: | IgE induction by parasites and allergens is antigen driven and cognate T cell help dependent. We demonstrate that spontaneously produced IgE in T cell-deficient and germ-free wild-type (wt) mice is composed of natural specificities and induced by a mechanism independent of MHC class II (MHC II) cognate help. This does not require secondary lymphoid structures or germinal center formation, although some bystander T cell-derived IL-4 is necessary. The pathway of spontaneous IgE production is not inhibited by regulatory T cells and increases with age to constitute significant serum concentrations, even in naive animals. |
| Databáze: | OpenAIRE |
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