| Autor: |
Meyer-Luehmann, Melanie, Coomaraswamy, Janaky, Bolmont, Tristan, Kaeser, Stephan, Schaefer, Claudia, Kilger, Ellen, Neuenschwander, Anton, Abramowski, Dorothee, Frey, Peter, Jaton, Anneliese L., Vigouret, Jean-Marie, Paganetti, Paolo, Walsh, Dominic M., Mathews, Paul M., Ghiso, Jorge, Staufenbiel, Matthias, Walker, Lary C., Jucker, Mathias |
| Předmět: |
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| Popis: |
Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo. Intracerebral injection of dilute, amyloid-beta (A beta)-containing brain extracts from humans with Alzheimer's disease or beta-amyloid precursor protein (APP) transgenic mice induced cerebral beta-amyloidosis and associated pathology in APP transgenic mice in a time- and concentration-dependent manner. The seeding activity of brain extracts was reduced or abolished by A beta immunodepletion, protein denaturation, or by A beta immunization of the host. The phenotype of the exogenously induced amyloidosis depended on both the host and the source of the agent, suggesting the existence of polymorphic A beta strains with varying biological activities reminiscent of prion strains. |
| Databáze: |
OpenAIRE |
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