| Autor: |
Bosch, Pablo Sanchez, Makhijani, Kalpana, Herboso, Leire, Gold, Katrina S., Baginsky, Rowan, Woodcock, Katie J., Alexander, Brandy, Kukar, Katelyn, Corcoran, Sean, Jacobs, Thea, Ouyang, Debra, Wong, Corinna, Ramond, Elodie J. V., Rhiner, Christa, Moreno, Eduardo, Lemaitre, Bruno, Geissmann, Frederic, Bruckner, Katja |
| Předmět: |
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| Popis: |
The use of adult Drosophila melanogaster as a model for hematopoiesis or organismal immunity has been debated. Addressing this question, we identify an extensive reservoir of blood cells (hemocytes) at the respiratory epithelia (tracheal air sacs) of the thorax and head. Lineage tracing and functional analyses demonstrate that the majority of adult hemocytes are phagocytic macrophages (plasmatocytes) from the embryonic lineage that parallels vertebrate tissue macrophages. Surprisingly, we find no sign of adult hemocyte expansion. Instead, hemocytes play a role in relaying an innate immune response to the blood cell reservoir: through Mid signaling and the Jak/Stat pathway ligand Upd3, hemocytes act as sentinels of bacterial infection, inducing expression of the antimicrobial peptide Drosocin in respiratory epithelia and colocalizing fat body domains. Drosocin expression in turn promotes animal survival after infection. Our work identifies a multisignal relay of organismal humoral immunity, establishing adult Drosophila as model for inter-organ immunity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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