Combined Hormone and Brachy Therapies for the Treatment of Prostate Cancer

Autor: Chabbar, Salma, Habbal, Abderrahmane, Aboulaich, Rajae, Ismaili, Nabil, El Majjaoui, Sanaa
Přispěvatelé: Analysis and Control of Unsteady Models for Engineering Sciences (ACUMES), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire d'Etudes et Recherche en Mathématiques Appliquées (LERMA), Ecole Mohammadia d'Ingénieurs (EMI), Université Mohammed VI Polytechnique [Ben Guerir] (UM6P), Université Mohammed VI des Sciences de la Santé [Casablanca] (UM6SS), National Institute of Oncology, CHU Avicenne
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Popis: Prostate cancer is a hormone-dependent cancer characterized by two types of cancer cells, androgen-dependent cancer cells and androgen-resistant ones. The objective of this paper is to present a novel mathematical model for the treatment of prostate cancer under combined hormone therapy and brachytherapy. Using a system of partial differential equations, we quantify and study the evolution of the different cell densities involved in prostate cancer and their responses to the two treatments. Numerical simulations of tumor growth under different therapeutic strategies are explored and presented. The numerical simulations are carried out on FreeFem++ using a 2D finite element method.
Databáze: OpenAIRE