Cardiac arrhythmias and Griffiths phase: desynchronization of excitable cells
| Autor: | Attuel, Guillaume, Yahia, Hussein |
|---|---|
| Přispěvatelé: | Geometry and Statistics in acquisition data (GeoStat), Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Work partially supported by FP7/2007-2013 and CAVERNOM 2014-1R60612-00003295, ENS Lyon, IUPAP, CNRS, Université de Lyon |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Gap junction polarization
Memory Domain growth Cardiac Arrhythmias [NLIN.NLIN-CD]Nonlinear Sciences [physics]/Chaotic Dynamics [nlin.CD] Intermittency [PHYS.COND.CM-DS-NN]Physics [physics]/Condensed Matter [cond-mat]/Disordered Systems and Neural Networks [cond-mat.dis-nn] [PHYS.COND.CM-SM]Physics [physics]/Condensed Matter [cond-mat]/Statistical Mechanics [cond-mat.stat-mech] Collective phenomena |
| Zdroj: | STATPHYS 26 IUPAP; ENS Lyon; CNRS; Université de Lyon. STATPHYS 26, Jul 2016, Lyon, France. STATPHYS26-Palais des Congres-Lyon 18-22 July 2016, 2017 |
| Popis: | https://statphys26.sciencesconf.org/; International audience; Challenges of C arrhythmias raised by the data:1-Most frequent cause of embolic stroke (AF),with evolution to chronic disease. Major causeof natural death (VF), about 5% only are saved.2-Hysteresis: strike twice and patient resuscitates.3-Most models refer to chaotic dynamics, but thisdoes not describe spontaneous reversions tolesser C arrhythmias.Some features suggest intrinsic disorder:1-The data show intermittency of beat-to-beatintervals and peaks amplitude.2-Slow evolution of vulnerability (thesusceptibility), so called remodeling.Conduction velocity is not known to be very much affected. Intermittency may instead reveal nucleation and contamination processes à laPomeau. However, the medium is excitable and excitability is a robust cycle to any homo- or heteroclinic nucleation. Alteration of conduction, e.g. on a nearly percolating fibrotic substrate, yields fancy anatomical reentries, but no such intermittent behavior. We believe that the data is suggestive of fragmented pulses, following from the desynchronization of the network of electrically coupled excitable cells. |
| Databáze: | OpenAIRE |
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