| Autor: |
Kim, Jin-Young, Petreus, T., Fluri, David, Kelm, Jens, Tang, E.K.Y., Hierlemann, Andreas, Frey, Olivier |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2015) |
| Popis: |
A simple in vitro model for human organ-to-organ interaction studies was realized by using spherical microtissues (MTs) cultured in a 96-well-format-based microfluidic platform. The model was validated by comparing the bio-activation effects of an anti-cancer pro-drug, cyclophosphamide (CPA), under static and perfusion conditions in a liver-tumor network. Primary human liver (hLi) MTs and human colon carcinoma (HCT116) MTs were fluidically interconnected for realizing a liver-tumor model in a physiological environment. Medium was perfused through microfluidic channels without tubing and pumps by using a gravity-driven flow concept. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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