| Autor: |
Ruan, Yue, Thabit, Hood, Leelarathna, Lalantha, Hartnell, Sara, Willinska, Malgorzata E, Dellweg, Sibylle, Benesch, Carsten, Mader, Julia K, Holzer, Manuel, Kojzar, Harald, Evans, Mark L, Pieber, Thomas R, Arnolds, Sabine, Hovorka, Roman, AP@home Consortium |
| Přispěvatelé: |
Evans, Mark [0000-0001-8122-8987], Hovorka, Roman [0000-0003-2901-461X], Apollo - University of Cambridge Repository |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Popis: |
OBJECTIVE: To quantify variability of insulin requirements during closed-loop insulin delivery. RESEARCH DESIGN AND METHODS: We retrospectively analyzed overnight, daytime, and total daily insulin amounts delivered during a multicenter closed-loop trial involving 32 adults with type 1 diabetes. Participants applied hybrid day-and-night closed-loop insulin delivery under free-living home conditions over 12 weeks. The coefficient of variation was adopted to measure variability of insulin requirements in individual subjects. RESULTS: Data were analyzed from 1,918 nights, 1,883 daytime periods and 1,564 total days characterized by closed-loop use over 85% of time. Variability of overnight insulin requirements (mean [SD] coefficient of variation 31% [4]) was nearly twice as high as variability of total daily requirements (17% [3], P < 0.001) and was also higher than variability of daytime insulin requirements (22% [4], P < 0.001). CONCLUSIONS: Overnight insulin requirements were significantly more variable than daytime and total daily amounts. This may explain why some people with type 1 diabetes report frustrating variability in morning glycemia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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