| Autor: |
Jakobczyk, Hélène, Jiang, Yan, Debaize, Lydie, Soubise, Benoit, Avner, Stéphane, Sérandour, Aurélien A, Rouger-Gaudichon, Jérémie, Rio, Anne-Gaëlle, Carroll, Jason S, Raslova, Hana, Gilot, David, Liu, Ziling, Demengeot, Jocelyne, Salbert, Gilles, Douet-Guilbert, Nathalie, Corcos, Laurent, Galibert, Marie-Dominique, Gandemer, Virginie, Troadec, Marie-Bérengère |
| Přispěvatelé: |
Jiang, Yan [0000-0002-5005-0642], Debaize, Lydie [0000-0003-3718-3210], Demengeot, Jocelyne [0000-0002-4761-614X], Salbert, Gilles [0000-0001-6115-4140], Galibert, Marie-Dominique [0000-0003-0095-742X], Troadec, Marie-Bérengère [0000-0003-2668-9670], Apollo - University of Cambridge Repository |
| Rok vydání: |
2022 |
| Předmět: |
|
| Popis: |
ETV6-RUNX1 and RUNX1 directly promote RAG1 expression. ETV6-RUNX1 and RUNX1 preferentially bind to the −1200 bp enhancer of RAG1 and the −80 bp promoter of RAG1 gene respectively, and compete for these bindings. ETV6-RUNX1 and RUNX1 induce an excessive RAG recombinase activity. ETV6-RUNX1 participates directly in two events of the multi-hit ALL leukemogenesis: as an initiating event and as an activator of RAG1 expression. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
