| Autor: |
Glont, Silvia-E, Chernukhin, Igor, Carroll, Jason S |
| Přispěvatelé: |
Carroll, Jason [0000-0003-3643-0080], Apollo - University of Cambridge Repository |
| Rok vydání: |
2019 |
| Předmět: |
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| Popis: |
Considerable work has linked hormone receptors, such as estrogen receptor-alpha (ER), with the pioneer factor FOXA1. Altered FOXA1 levels contribute to endocrine-resistant breast cancer, where it maintains ER-chromatin interactions, even in contexts in which cells are refractory to ER-targeted drugs. A recent study controversially suggests that FOXA1 binding can be induced by hormonal pathways, including the estrogen-ER complex. We now show that the vast majority (>99%) of FOXA1 binding events are unaffected by steroid activation. A small number ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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