| Autor: |
Broekman, M M T J, Coenen, Marieke J H, Wanten, Geert J A, van Marrewijk, C. J., Klungel, O. H., Verbeek, A. L.M., Hooymans, Piet M, Guchelaar, H.J., Scheffer, H., Derijks, Luc J J, Wong, Dennis R, de Jong, D. J. |
| Přispěvatelé: |
Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Popis: |
Background: Leucopenia is a common side effect in patients treated with thiopurines. Variants in the thiopurine S-methyltransferase (TPMT) gene are the best-known risk factor, but only explain up to 25% of leucopenia cases. Aim: To identify the clinical risk factors for thiopurine-induced leucopenia in patients without a common TPMT variant, and explore if these patients are at increased risk for infections. Methods: Post hoc analysis of the Thiopurine response Optimisation by Pharmacogenetic testing in Inflammatory bowel disease Clinics (TOPIC) trial. For this analysis, patients without a variant in TPMT (*2, *3A or*3C) were included. Uni- and multivariate Cox-proportional hazard models were used to identify risk factors for leucopenia and infections. Leucopenia was defined as a white blood cell (WBC) count |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
