| Autor: |
Keijser, S F A, Fieten, H, Vos-Loohuis, M, Piek, C J, Anderson, H, Donner, J, Scholten, I, Nielen, M, Hesselink, J W, van Steenbeek, F G |
| Přispěvatelé: |
Onderzoek, LS Interne geneeskunde, dCSCA AVR, Biochemisch laboratorium, Sub Hematologie, LS Evidence Based Vet Medicine, dFAH AVR, dCSCA RMSC-1 |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
Background: Selective breeding in populations with a limited effective population size may result in a loss of genetic diversity, which can cause an increased concentration of specific disease liability genes. The Dutch Shepherd Dog (DSD) in the Netherlands is an example of such a breed with a small effective population. Objective: To evaluate the measurement of genetic diversity and multiplex DNA panel screening for implementation in a breeding strategy for the Dutch Shepherd Dog (DSD) and to investigate the clinical relevance of potentially identified mutations in the multiplex DNA panel screening. Results: Genome-wide SNP testing showed genetic isolation and reduced genetic diversity within coat variety subgroups of the DSD. Panel screening identified a Von Willebrand's Disease type I mutation. Although decreased Von Willebrand's Factor proteins were significantly lower in DSDs carrying the VWD-I allele compared to the wildtype, clinical follow-up did not show a significant association between the clinical phenotype and VWD-I genotype. Conclusions: Genetic relationship measurement within a breed population may be a useful tool to enable breeding strategies to conserve genetic diversity. Results from a disease panel screening need to be evaluated for clinical relevance before breed selection restrictions can be considered. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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