| Autor: |
Vis, Roeland, Malviya, Gaurav, Signore, Alberto, Grutters, Jan C, Meek, Bob, van de Garde, Ewoudt M W, Keijsers, Ruth G M |
| Přispěvatelé: |
Sub Pharmacotherapy, Theoretical, Pharmacoepidemiology and Clinical Pharmacology |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
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| Popis: |
Infliximab, a monoclonal antibody directed against tumour necrosis factor (TNF)-α, is used in the treatment of refractory sarcoidosis. However, the clinical response is variable and a tool to select responders beforehand is highly desirable. In this study we evaluated scintigraphy with technetium-99m ((99m)Tc)-labelled infliximab for the imaging of disease activity in patients with pulmonary sarcoidosis.10 patients were studied using single photon emission computed tomography/computed tomography (CT) 6 h and 20 h after intravenous administration of 370 MBq of (99m)Tc-infliximab. Correlation analysis was performed between tissue accumulation of (99m)Tc-infliximab and laboratory parameters (including soluble interleukin-2 receptor and angiotensin-converting enzyme), lung function parameters (including forced expiratory volume in 1 s and the diffusing capacity of the lung for carbon monoxide) and (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT.Analysis showed selective and variable accumulation of (99m)Tc-infliximab in the target tissue. Accumulation correlated positively with all four laboratory parameters and negatively with all four lung function parameters, yielding better correlations than serum TNF-α levels or (18)F-FDG PET/CT.(99m)Tc-infliximab accumulation reflects the in situ TNF-α expression in an individual patient and therefore provides valuable information on the presence of the biological target for anti-TNF-α therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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