New developments in the molecular treatment of ichthyosis

Jazyk:	angličtina
Rok vydání:	2022
Předmět:	NETHERTON SYNDROME CHILD SYNDROME SEVERE DERMATITIS Small molecule therapy Ichthyosis RECESSIVE CONGENITAL ICHTHYOSIS Replacement therapy Management CORRECTIVE GENE-TRANSFER PITYRIASIS-RUBRA-PILARIS Gene therapy MULTIPLE ALLERGIES ENZYME-REPLACEMENT THERAPY ALDEHYDE DEHYDROGENASE-DEFICIENCY Biological therapy SKIN
Zdroj:	Orphanet Journal of Rare Diseases. 17(1)
ISSN:	1750-1172
DOI:	10.1186/s13023-022-02430-6
Popis:	Ichthyosis covers a wide spectrum of diseases affecting the cornification of the skin. In recent years, new advances in understanding the pathophysiology of ichthyosis have been made. This knowledge, combined with constant development of pathogenesis-based therapies, such as protein replacement therapy and gene therapy, are rather promising for patients with inherited skin diseases. Several ongoing trials are investigating the potency of these new approaches and various studies have already been published. Furthermore, a lot of case series report that biological therapeutics are effective treatment options, mainly for Netherton syndrome and autosomal recessive congenital ichthyosis. It is expected that some of these new therapies will prove their efficacy and will be incorporated in the treatment of ichthyosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od________83::a8c4ca07d6885ef80327a4ddc129d329 https://doi.org/10.1186/s13023-022-02430-6 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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