| Autor: |
Banala, Sambashiva, Arvin, Matthew C., Bannon, Nicholas M., Jin, Xiao-Tao, Macklin, John J., Wang, Yong, Peng, Can, Zhao, Guiqing, Marshall, John J., Gee, Kyle R., Wokosin, David L., Kim, Veronica J., McIntosh, J. Michael, Contractor, Anis, Lester, Henry A., Kozorovitskiy, Yevgenia, Drenan, Ryan M., Lavis, Luke D. |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Popis: |
Photoactivatable pharmacological agents have revolutionized neuroscience, but the palette of available compounds is limited. We describe a general method for caging tertiary amines by using a stable quaternary ammonium linkage that elicits a red shift in the activation wavelength. We prepared a photoactivatable nicotine (PA-Nic), uncageable via one- or two-photon excitation, that is useful to study nicotinic acetylcholine receptors (nAChRs) in different experimental preparations and spatiotemporal scales. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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