Regulation of energy metabolism in human skeletal muscle cells and adipocytes: Effects of SENP2 knockdown and conditioned medium from human pancreatic carcinoma cells

Autor: Krapf, Solveig A.
Jazyk: angličtina
Rok vydání: 2022
Popis: Obesity and cancer are increasing world-wide health problems. Though healthy lifestyle choices such as a balanced diet and regular exercise are effective strategies to counter the disease risks, effective treatment and preventive options are often limited. For example physical actively is not always possible and in addition, some cancers, such as pancreatic cancer, show few symptoms until progressed to a late stage. We are therefore in need of better options to treat and diagnose these conditions. In this work we look at a protein, SENP2, which previously has been shown to regulate energy metabolisms in skeletal muscle and fat tissue in rodent. Herein we revealed that SENP2 plays an important role in energy metabolism also in human skeletal muscle and fat cells, by regulating several important genes and proteins. We also revile new insight into pancreatic cancer cell energy metabolism and how the cancer also affects energy metabolism in other tissues, such as skeletal muscle. These results will be a valuable resource to understand energy metabolism and the complex interplay between different tissues in the combat against obesity and cancer.
Databáze: OpenAIRE