| Přispěvatelé: |
Stanković, Ivana, Ristić, Lidija, Rančić, Milan, Lazić, Zorica, Pejčić, Tatjana |
| Popis: |
There is an abnormal inflammatory pulmonary response to harmful particles or gases in chronic obstructive pulmonary disease (COPD). Pulmonary inflammation spills over into systemic circulation which causes extra pulmonary manifestations. A large number of inflammatory mediators are involved in establishing and maintaining of inflammatory response. The aim of the research was the analysis of systemic effects of inflammation and COPD severity. The examination was done in the Clinic for Pulmonary Diseases Knez Selo, Clinical Center Niš, and it involved 85 patients with COPD in a stable phase. The patients were divided into four groups: mild, moderate, severe and very severe COPD. Serum values of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-α) and leptin were measured, BODE index was determined, and the presence of weight loss and muscle loss, muscle dysfunction and osteoporosis were determined. We found that with the increase in COPD severity, values of CRP, TNF-α and leptin varied in the range that was not statistically significant. CRP had positive, and TNF-α negative predictive influence on COPD severity. The increase in disease severity was followed by borderline statistically significant increase in frequency of underweight and borderline nutrition (p=0.05). Leptin values of underweight and normal nutrition were significantly different from leptin values of pre-obese and obese (p |
