| Autor: |
MULDER, NH, TIMMERBOSSCHA, H, MEERSMA, GJ, VERSCHUEREN, RCJ |
| Jazyk: |
angličtina |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Anticancer Research, 14(6B), 2677-2680. INT INST ANTICANCER RESEARCH |
| ISSN: |
0250-7005 |
| Popis: |
Catalytic activity and FdUMP binding characteristics of thymidylate synthase (TS) were determined in 22 rumor biopsies of patients to be treated (15) or just treated (7) for colorectal cancer with 5-fluorouracil and leucovorin. In 19 samples both parameters could be determined and were found to represent a wide range (15-20 fold). High values of activity correlated with no response, bur low values of binding or activity were found in responders as well as in non-responders. It is concluded that the determination of parameters related to TS function is feasible in tumor biopsies and its relevance for clinical management deserves further study. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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