| Autor: |
Cohen, Judith, Postma, Dirkje S., Vink-Klooster, Karin, van der Bij, Wim, Verschuuren, Erik, ten Hacken, Nick H. T., Koeter, Gerard H., Douma, W. Rob |
| Přispěvatelé: |
Faculteit Medische Wetenschappen/UMCG, Lifestyle Medicine (LM), Groningen Research Institute for Asthma and COPD (GRIAC), Groningen Institute for Organ Transplantation (GIOT) |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Chest, 132(4), 1198-1203. ELSEVIER SCIENCE BV |
| ISSN: |
0012-3692 |
| Popis: |
Background: The ratio of FVC to slow inspiratory vital capacity (SVC) has been reported to reflect small airways obstruction, but its validity as such is still unclear. The aim of this study was to assess the applicability of the FVC/SVC ratio as a marker of small airways function in patients with bronchiolitis obliterans syndrome (BOS) after lung transplantation (LTX), which is a disorder in which predominantly small airways obstruction causes progressive airflow limitation. Methods: The FVC/SVC ratio was analyzed both cross-sectionally and longitudinally in 39 patients (26 men) with BOS after bilateral LTX (median age, 47 years; interquartile range [IQR], 35 to 54 years), and 36 bilateral lung transplant recipients without BOS (14 men; median age, 46 years; IQR, 41 to 53 years). Results: The FVC/SVC ratio decreased significantly during follow-up in patients with BOS stages I and 2, by 2.2% and 4.4%, respectively, from baseline (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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