Activity-state profile of tau kinases in hibernating animals
| Autor: | Stieler, Jens T., Boerema, A.S., Bullmann, Torsten, Kohl, Franziska, Strijkstra, Arjen, Barnes, Brian M., Lovegrove, Barry G., McKechnie, Andrew E. |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Zdroj: | Hypometabolism in animals: Hibernation, torpor and cryobiology, 133-142 STARTPAGE=133;ENDPAGE=142;TITLE=Hypometabolism in animals |
| Popis: | A variety of neurological disorders including Alzheimer's disease are associated with the formation of neurofibrillary tangles, made up by intraneuronal paired helical filaments (PHFs) that are composed of hyperphosphorylated tau protein. The phosphorylation of tau is assumed to be crucial for aggregation; however, the underlying mechanisms are not well understood. Several kinases have been identified as potential candidates for the abnormal phosphorylation under pathological conditions. Nevertheless, based on the lack of appropriate models the actual relevance of these enzymes could not be studied concertedly under physiological conditions. Recently, we described the reversible formation of highly phosphorylated tau protein in hibernating animals under physiological conditions. Using hibernation as a model we determined the activity profile of four major tau kinases in three different species to analyse the state-dependent regulation of these enzymes and reveal the importance of each kinase for tau phosphorylation. |
| Databáze: | OpenAIRE |
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