| Autor: |
Verhagen, Martijn V, Levolger, Stef, Hulshoff, Jan Binne, Werner, Maureen J M, van der Doef, Hubert P J, Viddeleer, Alain R, de Kleine, Ruben H, de Haas, Robbert J |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Zdroj: |
Liver Transplantation, 27(12), 1179-1787. Wiley |
| ISSN: |
1527-6465 |
| Popis: |
BACKGROUND: Computed tomography (CT) derived body metrics such as skeletal muscle index (SMI), psoas muscle index (PMI), and subcutaneous fat index (ScFI) are measurable components of sarcopenia, frailty, and nutrition. While these body metrics are advocated in adults for predicting postoperative outcomes after liver transplantation (LT), little is known about the value in pediatric populations. This study assessed the relation between preoperative CT-based body metrics and postoperative short-term outcomes in pediatric LT recipients. METHODS: Patients aged 0-18 years who underwent a primary LT were retrospectively included (N=101, median age 0.5 years, range 0.2-17.1). SMI, PMI, and ScFI were derived from preoperative axial CT slices. Postoperative outcomes and complications within 90 days were correlated with the CT-based body metrics. To classify postoperative infections, the Clavien-Dindo (CD) classification was used. Subgroup analyses were performed for age groups (10 years old). An optimal threshold for test performance was defined using Youden's J-statistic and receiver operating characteristic curve as appropriate. RESULTS: ScFI was significantly (P=0.001) correlated with moderate to severe postoperative infections (CD grade 3-5) in children |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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