| Autor: |
Franco, RF, Middeldorp, S, Meinardi, [No Value], van Pampus, ECM, Reitsma, PH |
| Jazyk: |
angličtina |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
British Journal of Haematology, 111(1), 118-121. Wiley |
| ISSN: |
0007-1048 |
| Popis: |
A mutation in factor XIII (Val34Leu) was reported to protect against Venous thromboembolism. We evaluated the effect of Val34Leu on thrombotic risk in 352 factor V Leiden carriers who were first-degree relatives of 132 thrombotic propositi carrying factor V Leiden. The total observation period was 2594 years in 92 Val34Leu carriers and 7444 years in 260 non-carriers. The annual incidence of a first episode of venous thromboembolism was 0.31% in Val34Leu carriers and 0.44% in non-carriers [relative risk (RR) for Venous thromboembolism: 0.7, 95% CI 0.3-1.5]. Age-specific RR for Venous thromboembolism were (for Val34Leu carriers and non-carriers respectively): 1.0 (95% CT 0.3-3.2) in the age group of 15-30 years, 0.4 (95% CI 0.05-3.0) in the age group of 30-45 years, 0.6 (95% CI 0.1-2.9) in the group aged 45-60 years and 0.5 (95% CI 0.06-4.5) in relatives order than 60 years. In conclusion, the impact of FXIII Val34Leu on the venous thromboembolic risk is modest, suggesting that screening for this mutation in factor V Leiden carriers is not justified. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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