| Autor: |
Chesik, D., Glazenburg, K., Wilczak, N., Geeraedts, Felix, De Keyser, J. |
| Jazyk: |
Dutch; Flemish |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Neuroreport, 15(6), 1033-1037. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: |
0959-4965 |
| Popis: |
In the CNS insulin-like growth factor-1 (IGF-1) enhances survival of neurons, promotes myelin synthesis and acts as a mitogen for microglia. The effects of IGF-1 are regulated by a family of 6 IGF binding proteins (IGFBPs). We investigated mRNA expression patterns of IGFBPs in primary rat microglia under basal conditions and after activation with lipopolysaccharide (LPS). Under basal conditions, microglia expressed IGFBP-2 to -6, whereas, IGFBP-1 could not be detected. Following 2 h treatment with LPS mRNA levels for IGFBP-4 and -6 displayed a down regulation, and IGFBP-5 became undetectable. Levels of IGFBP-2 and -3 remained unaltered. Expression patterns of IGFBPs might play an important role in regulating the autocrine/paracrine IGF-1 actions on microglia under inflammatory conditions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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