| Autor: |
Lowenberg, B, Boogaerts, MA, Daenen, SMGJ, Verhoef, GEG, Hagenbeek, A, Vellenga, E, Ossenkoppele, GJ, Huijgens, PC, Verdonck, LF, vanderLelie, J, Wielenga, JJ, Gmur, J, Gratwohl, A, Hess, U, Fey, MF, vanPutten, WLJ |
| Přispěvatelé: |
Faculteit Medische Wetenschappen/UMCG, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Stem Cell Aging Leukemia and Lymphoma (SALL) |
| Jazyk: |
angličtina |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
Journal of Clinical Oncology, 15(12), 3496-3506. AMER SOC CLINICAL ONCOLOGY |
| ISSN: |
0732-183X |
| Popis: |
Purpose: The hematopoietic growth factors (HGFs) introduced into induction chemotherapy (CT) of acute myeloid leukemia (AML) might be of benefit to treatment outcome by at least two mechanisms. HGFs given on days simultaneously with CT might sensitize the leukemic cells and enhance their susceptibility to CT. HGFs applied after CT might hasten hematopoietic recovery and reduce morbidity or mortality. Materials and Methods: We set out to evaluate the use of granulocyte-macrophage colony-stimulating factor (GM-CSF; 5 mu g/kg) in a prospective randomized study of factorial design (yes or no GM CSF during CT, and yes or no GM-CSF after CT) in patients aged 15 to 60 years (mean, 42) with newly diagnosed AML. GM-CSF was applied as follows: during CT only (+/-, n = 64 assessable patients), GM-CSF during and following CT (+/+, n = 66), no GM-CSF (-/-, n = 63), or GM-CSF after CT only (-/+, n = 60). Results: The complete response (CR) rate wets 77%. At a median follow-up time of 42 months, probabilities of overall survival (OS) and disease-free survival (DFS) at 3 years were 38% and 37% in all patients. CR rates, OS, and DFS did not differ between the treatment groups (intention-to-treat analysis). Neutrophil recovery (1.0 x 10(9)/L) and monocyte recovery were significantly faster in patients who received GM-CSF after CT (26 days v 30 days; neutrophils, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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