| Autor: |
ter Maaten, JC, Bakker, SJL, Serne, EH, Moshage, HJ, Gans, ROB |
| Přispěvatelé: |
Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE) |
| Jazyk: |
angličtina |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
European Journal of Clinical Investigation, 30(12), 1090-1098. Wiley |
| ISSN: |
0014-2972 |
| Popis: |
Background Impaired vasodilatation in skeletal muscle is a possible mechanism linking insulin resistance to blood pressure regulation. Increased renal vascular resistance has been demonstrated in the offspring of essential hypertensives. We assessed whether insulin-mediated renal vasodilatation is impaired in insulin-resistant normal subjects. Design In two groups of 10 insulin-resistant and 10 insulin-sensitive normal subjects, we compared the effects of sequential physiological and supraphysiological insulin dosages (50 and 150 mU kg(-1) h(-1)) on renal plasma flow (RPF) and leg blood flow using the euglycaemic clamp technique, I-131-labelled Hippuran clearances and venous occlusion plethysmography. Time-control experiments were performed in the same subjects. Results Whole-body glucose uptake amounted to 4.9 +/- 2.1 and 11.0 +/- 2.4 mg kg (-1)min(-1) in the insulin-resistant and to 12.7 +/- 2.3 and 17.4 +/- 2.6 mg kg (-1)min(-1) in the insulin-sensitive subjects during physiological and supraphysiological hyperinsulinaemia, respectively. RPF increased more in insulin-sensitive compared to insulin-resistant subjects during physiological hyperinsulinaemia (13.7 vs. 6.8%, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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